The term “primary” shows no known cause such as trauma, pigmentation, exfoliation, or inflammation for the development of this glaucoma. These changes are usually associated with increased IOP. Primary open-angle glaucoma (POAG) can be defined as a progressive optic nerve disease that can lead to deterioration of visual field. There are different types of glaucoma among them, the two most common in Scandinavia are primary open-angle (POAG) and exfoliation glaucoma (EXFG). Increased intraocular pressure (IOP) is the most common risk factor. Still, the cause of glaucoma is unknown, but several risk factors have been described. Until now, no treatment has been discovered to cure the disease, and its character is progressive. Loss of ganglion cells with a consequent loss of visual field characterized the disease. It’s one of the most common causes of blindness in western countries. Glaucoma is an optic neuropathy that can lead to blindness. New-diagnosed exfoliation glaucoma patients must be controlled and treated more strictly than primary open-angle glaucoma patients to avoid visual field deterioration. The present study found a more frequent and faster visual field progression in exfoliation than in primary open-angle glaucoma patients. The GPA showed progression in 58% of cases in exfoliation, and 13% in primary open glaucoma group (Chi-square, p = < 0.001). The difference was higher in the exfoliation (− 7.65%) than in the primary open (− 1.90%) glaucoma group (t-test, p = < 0.001). The difference in VFI was calculated for the 3 years follow-up period. The difference between groups was significant (t-test, p = < 0.001). The MD difference values were higher in the exfoliation (− 3.17 dB) than in the primary open-angle (− 1.25 dB) glaucoma group in the three-year follow-up period. The study included 128 subjects, of the 54 in the open-angle and 74 in the exfoliation glaucoma group. For visual field progression, three different strategies were used: mean deviation (MD), visual field index (VFI), and the guided progression analysis (GPA). Visual field evaluation was performed using the software threshold 24–2 of the Humphrey Field Analysis. Exfoliation and open-angle glaucoma were defined based on the European Glaucoma Society guidelines. At least five reliable fields were needed for inclusion. All patients were followed for 3 years with reliable visual fields. The study included patients with new-diagnosed primary open-angle and exfoliation glaucoma. The present study aimed to compare visual field progression in new-diagnosed exfoliation versus open-angle glaucoma patients.
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